顾昕;徐菲;张丽玲;王云玲;丁爽;

• 1:新疆医科大学第一附属医院磁共振室

摘要(Abstract)：

目的 通过应用T1三维磁化强度预备梯度回波(T1 three dimensional magnetization prepared rapid acquisition gradient echo,3D-T1 MPRAGE)序列及FreeSufer软件测量海马及杏仁核体积，研究颞叶内侧癫痫(medial temporal lobe epilepsy,MTLE)患者的杏仁核体积变化。材料与方法 前瞻性纳入102例MTLE患者(病例组)和15例健康志愿者(对照组)，分别测量双侧海马、杏仁核的体积，以对照组体积的平均值加减2倍标准差作为阈值来判断海马及杏仁核的异常。根据海马体积是否正常，将海马硬化(hippocampal sclerosis,HS)组、海马正常组中杏仁核肥大(amygdala enlargement,AE)患者按致癫侧分为L组、R组，使用配对t检验进行双侧杏仁核体积比较，并使用单因素方差分析将海马正常组-L组、海马正常组-R组及对照组同侧杏仁核进行比较；HS组-L组、HS组-R组及对照组同侧杏仁核进行比较。结果 研究发现，海马正常组-L组、海马正常组-R组双侧杏仁核体积差异有统计学意义(P<0.05),HS组-L组、HS组-R组双侧杏仁核体积差异有统计学意义(P<0.05);HS组-L组中右侧杏仁核体积大于HS组-R组及对照组同侧，差异有统计学意义(P<0.05),HS组-R组左侧杏仁核体积大于HS组-L组及对照组同侧,差异有统计学意义(P<0.05)；海马正常组-L组中左侧杏仁核体积大于海马正常组-R组及对照组同侧，差异有统计学意义(P<0.05)，海马正常组-R组右侧杏仁核体积大于海马正常组-L组及对照组同侧，差异有统计学意义(P<0.05)。结论 3D-T1 MPRAGE可以准确测量杏仁核体积，同时MTLE中海马正常患者存在致癫灶同侧的AE,HS患者存在致癫灶对侧AE，表明杏仁核可能参与了MTLE的发生与发展。

关键词(KeyWords)： 颞叶内侧癫痫;海马;杏仁核体积;磁共振成像;T1三维磁化强度预备梯度回波序列

Abstract:

Keywords:

基金项目(Foundation): 新疆维吾尔自治区科技支疆项目计划(指令性)项目(编号：2020E0275)~~

作者(Authors): 顾昕;徐菲;张丽玲;王云玲;丁爽;

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