党玉雪;王晓明;

• 1:中国医科大学附属盛京医院放射科

摘要(Abstract)：

磁共振成像(MRI)技术在评估脑的解剖结构及功能变化方面得到日益广泛的应用。扩散峰度成像(DKI)是用于量化组织内水分子非高斯运动的磁共振新技术,是扩散成像技术的延伸,对于描绘脑组织微观结构具有独特优势。体素内不相干运动成像(IVIM)是近几年发展起来的无创评价活体组织内分子扩散运动及灌注的MRI新技术。本文对DKI和IVIM的成像原理以及对中枢神经系统的应用价值的研究进展予以综述。

关键词(KeyWords)： 脑;磁共振;扩散峰度成像;体素内不相干运动成像

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(编号:30570541,30770632,81271631)

作者(Author): 党玉雪;王晓明;

Email:

参考文献(References)：

• [1]Shan Y,Lu J,Li KC.Progresses in diffusional kurtosis imaging of ischemic stroke.Chin J Med Imaging Technol,2013,29(12):2046-2048.单艺,卢洁,李坤成.扩散峰度成像在缺血性脑卒中的研究进展.中国医学影像技术,2013,29(12):2046-2048.
• [2]Le Bihan D,Breton E,Lallemand D,et al.MR imaging of introvoxel incoherent motions:application to diffusion and perfusion in neurologic disorder.Radiology,1986,161(2):401-407.
• [3]Jensen JH,Helpern JA,Ramani A,et al.Diffusional kurtosis imaging:the quantification of non-gaussian water diffusion by means of magnetic resonance imaging.Magn Reson Med,2005,53(6):1432-1440.
• [4]Jensen JH,Helpern JA.MRI quantification of non-Gaussian water diffusion by kutosis analysis.NMR Biomed,2010,23(7):698-710.
• [5]Wu EX,Cheung MM.MR diffusion kurtosis imaging for neural tissue characterization.NMR Biomed,2010,23(7):836-848.
• [6]Zhou CW,Zhang RZ.Status and mission of the breast imaging.Chin J Magn Reson Imaging,2014,5(4):241-245.周纯武,张仁知.乳腺影像学的现状与使命.磁共振成像,2014,5(4):241-245.
• [7]Ichiron Y,Winn A,Yoshiro H,et al.Diffusion coefficients in abdominal organs and hepaticlesions:evaluation with intravoxel incoherent motion echo-planar MR imaging.Radiology,1999,210(3):617-623.
• [8]Le Bihan D,Breton E,Lallemand D,et al.Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging.Radiology,1988,168(2):497-505.
• [9]Le Bihan D.Intravoxel incoherent motion perfusion MR imaging:a wake-up call.Radiology,2008,249(3):748-752.
• [10]Raab P,Hattingen E,Franz K,et al.Cerebral gliomas:diffusional kurtosis imaging analysis of microstructural differences.Radiology,2010,254(3):876-881.
• [11]Van Cauter S,Veraart J,Sijbers J,et al.Gliomas:diffusion.Kurtosis MR imaging in grading.Radiology,2012,263(2):492-501.
• [12]Bisdas S,Koh TS,Roder C,et al.Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas:feasibility of the method and initial results.Neuroradiology,2013,55(10):1189-1196.
• [13]Hu YC,Yan LF,Wu L,et al.Intravoxel incoherent motion diffusionweighted MR Imaging of gliomas:efficacy in preoperative grading.Sci Rep,2014,4(12):7208.
• [14]Folkman J.Tumor angiogenesis:therapeutic implications.N Engl J Med,1971,285(21):1182-1186.
• [15]Li YC,Wang GB,Liu Q,et al.The pilot study of benign meningiomas using intravoxel incoherent motion imaging.J Med Imaing Vol,2014,24(3):461-464.李玉超,王光斌,刘强,等.体素内不相干运动扩散加权成像在良性脑膜瘤中的初步研究.医学影像学杂志,2014,24(3):461-464.
• [16]Ding J L,Xing W,Chen J,et al.The comparison between monoexponential and biexponential function of multi-b DWI in evaluation of clear cell renal cell carcinoma.Chin J Magn Reson Imaging,2013,4(4):266-270.丁玖乐,邢伟,陈杰,等.肾透明细胞癌多b值DWI得单指数函数与双指数函数分析比较.磁共振成像,2013,4(4):266-270.
• [17]Wang L,Li B,Xie S,et al.A study of IVIM and PWI of brain metastases at 3.0 T MR.J Med Imaing Vol,2014,24(3):337-341.王蕾,李斌,谢晟,等.3.0 T磁共振脑转移瘤IVIM与MR灌注加权成像的相关性研究.医学影像学杂志,2014,24(3):337-341.
• [18]Federau C,O’Brien K,Meuli R,et al.Measuring Brain Perfusion With Intravoxel Incoherent Motion(IVIM):Initial Clinical Experience.J Magn Reson Imaging,2014,39(3):624-632.
• [19]Suh CH,Kim HS,Lee SS,et al.Atypical Imaging Features of Primary Central Nervous System Lymphoma That Mimics Glioblastoma:Utility of Intravoxel Incoherent Motion MR Imaging.Radiology,2014,272(2):504-513.
• [20]Koeller KK,Smirniotopoulos JG,Jones RV.Primary central nervous system lymphoma:radiologic-pathologiccorrelation.Radiographics,1997,17(6):1497-1526.
• [21]Maeda M,Kawamura Y,Tamagawa Y,et al.Intravoxel incoherent motion(IVIM)MRI in intracranial,extraaxial tumors and cysts.J Comput Assist tomogr,1992,16(4):514-518.
• [22]Farrell JA,Zhang J,Jones MV,et al.q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy.Magn Reson Med,2010,63(5):1323-1335.
• [23]Jiang Q,Qu C,Chopp M,et al.MRI evaluation of axonal reorganization after bone marrow stromal cell treatment of traumatic brain injury.NMR Biomed,2011,24(9):1119-1128.
• [24]Zhuo J,Xu S,Proctor JL,et al.Diffusion kurtosis as an in vivo imaging marker for reactiven astrogliosis in traumatic brain injury.Neuroimage,2012,59(1):467-477.
• [25]Jensen JH,Falangola MF,Hu C,et al.Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction.NMR Biomed,2011,24(5):452-457.
• [26]Cheung JS,Wang E,Lo EH,et al.Stratification of heterogeneous diffusion MRI ischemic lesion with kurtosis imaging-Evaluation of mean diffusion and kurtosis MRI mismatch in an animal model of transient focal ischemia.Stroke,2012,43(8):2252-2254.
• [27]Hansen B,Lund T E,Sangill R,et al.Experimentally and computationally fast method for estimation of a mean kurtosis.Magn Reson Med,2013,69(6):1754-1760.
• [28]Sun PZ,Wang Y,Mandeville E,et al.Validation of fast diffusion kurtosis MRI for imaging acute ischemia in a rodent model of stroke.NMR Biomed,2014,11(27):1413-1418.
• [29]Neil JJ,Bosch CS,Ackerman JJ.An Evaluation of the Sensitivity of the Intravoxel Incoherent Motion(IVIM)Method of Blood Flow Measurement to Changes in Cerebral Blood Flow.Magn Reson Med,1994,32(1):60-65.
• [30]Federau C,Sumer S,Becce F,et al.Intravoxel incoherent motion perfusion imaging in acute stroke:initial clinical experience.Neuroradiology,2014,56(8):629-635.
• [31]Federau C,Maeder P,O’Brien K,et al.Quantitative measurement of brain perfusion with intravoxel incoherent motion MR imaging.Radiology,2012,265(3):874-881.
• [32]Helpern JA,Adisetiyo V,Falangola MF,et al.Preliminary Evidence of Altered Gray and White Matter Microstructural Development in the Frontal Lobe of Adolescents With Attention-Deficit Hyperactivity Disorder:A Diffusional Kurtosis Imaging Study.J Magn Reson Imaging,2011,33(1):17-23.
• [33]Kamagata K,Tomiyama H,Hatano T,et al.A preliminary diffusional kurtosis imaging study of Parkinson disease:comparison with conventional diffusion tensor imaging.Functional Neuroradiology,2014,56(3):251-258.
• [34]Lee CY,Tabesh A,Spampinato MV,et al.Diffusional kurtosis imaging reveals a distinctive pattern of microstrural alternations in idiopathic generalized epilepsy.Acta Neurol Scand,2014,130(3):148-155.
• [35]Blockx I,De Groof G,Verhoye M,et al.Microstructural changes observed with DKI in a transgenic Huntington rat model:evidencefor abnormal neurodevelopme.Neuroimage,2012,59(2):957-967.
• [36]Torre JC.Impaired cerebromicrovascular perfusion.Summary of evidence in support of its causality in Alzheimer’s disease.Ann N Y Acad Sci,2000,924(1):136-152.
• [37]Dong D,Wang XY.Magnetic resonance intravoxel incoherent motion in the diagnosis patients with mild cognitive impairment.Journal of Shangdong University(Health Sciences),2014,52(8):68-71.董栋,王新怡.磁共振体素内不相干运动在轻度认知功能障碍诊断中的意义.山东大学学报(医学版),2014,52(8):68-71.