高婷婷;王梦星;汤伟;董辽;杨光;杜小霞;马骏;

• 1:华东师范大学物理与电子科学学院上海市磁共振重点实验室
• 2:上海健康医学院医学影像学院
• 3:上海体育学院心理学院
• 4:上海交通大学医学院附属上海儿童医学中心发育与行为儿科

摘要(Abstract)：

目的 利用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)来探究夜间遗尿症(nocturnal enuresis,NE)儿童的自发脑活动改变机制。材料和方法 招募NE患者37例和性别、年龄和教育程度相匹配的健康对照(health control,HC)组37例，所有受试者接受rs-fMRI扫描，通过静息态数据计算NE患者组以及HC组的局部一致性(regional homogeneity,ReHo)和度中心性(degree centrality,DC)，使用t检验比较两组之间的差异，提取组间有差异脑区的DC值和ReHo值，与临床指标及《儿童睡眠习惯问卷》(Children's Sleep Habits Questionnaire,CSHQ)评分进行相关分析。结果 与HC组相比，NE患者组在前扣带回、海马旁回的DC值降低，前扣带回ReHo值降低。海马旁回的DC值与异态睡眠的评分呈正相关(P=0.045,r=0.256)，与CSHQ总分呈正相关(P=0.010,r=0.062)。结论 研究表明NE儿童其静息状态下局部脑功能活动降低，可能与NE的病理有密切关系。

关键词(KeyWords)： 夜间遗尿症;局部一致性;度中心性;磁共振成像;海马旁回;前扣带回

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(编号：81901720)~~

作者(Authors): 高婷婷;王梦星;汤伟;董辽;杨光;杜小霞;马骏;

参考文献(References)：

• [1]Tsai JD,Chen HJ,Ku MS,et al.Association between allergic disease,sleep-disordered breathing,and childhood nocturnal enuresis:a population-based case-control study[J].Pediatr Nephrol,2017,32(12):2293-2301.DOI:10.1007/s00467-017-3750-0.
• [2]Thurber S.Childhood enuresis:current diagnostic formulations,salient findings,and effective treatment modalities[J].Arch Psychiatr Nurs,2017,31(3):319-323.DOI:10.1016/j.apnu.2016.11.005.
• [3]Zhang J,Gao M,Jiang KH,et al.Study of resting state f MRI in children with primary nocturnal enuresis on degree centrality[J].Radiol Pract,2019,34(10):1077-1080.DOI:10.13609/j.cnki.1000-0313.2019.10.005.张静,高敏,江凯华,等.原发性夜间遗尿症儿童静息态f MRI度中心度的研究[J].放射学实践,2019,34(10):1077-1080.DOI:10.13609/j.cnki.1000-0313.2019.10.005.
• [4]Nevéus T.Pathogenesis of enuresis:towards a new understanding[J].Int J Urol,2017,24(3):174-182.DOI:10.1111/iju.13310.
• [5]Ferroni MC,Chaudhry R,Shen B,et al.Transcutaneous electrical nerve stimulation of the foot:results of a novel at-home,noninvasive treatment for nocturnal enuresis in children[J].Urology,2017,101:80-84.DOI:10.1016/j.urology.2016.10.023.
• [6]J?rgensen CS,Kamperis K,Borch L,et al.Transcutaneous electrical nerve stimulation in children with monosymptomatic nocturnal enuresis:a randomized,double-blind,placebo controlled study[J].JUrol,2017,198(3):687-693.DOI:10.1016/j.juro.2017.04.082.
• [7]Anyanwu OU,Ibekwe RC,Orji ML.Nocturnal enuresis among Nigerian children and its association with sleep,behavior and school performance[J].Indian Pediatr,2015,52(7):587-589.DOI:10.1007/s13312-015-0680-4.
• [8]Miniksar DY,Cans?z MA,K?l??M,et al.Relationship between sleep problems and chronotypes of children and adolescents with attention deficit and hyperactivity disorder and serum GABA,glutamate and homocysteine levels[J].Chronobiol Int,2022,39(3):386-397.DOI:10.1080/07420528.2021.2018452.
• [9]Gao YJ,Liu XM,Wang J,et al.Analysis of sleep status in children with primary nocturnal enuresis[J].Beijing Med J,2021,43(11):1070-1075.DOI:10.15932/j.0253-9713.2021.11.007.高杨洁,刘小梅,王佳,等.原发性夜遗尿症儿童睡眠状况分析[J].北京医学,2021,43(11):1070-1075.DOI:10.15932/j.0253-9713.2021.11.007.
• [10]von Gontard A,Mattheus H,Friese-Jaworsky J,et al.Incontinence and sleep disturbances in young children:a population-based study[J].Neurourol Urodyn,2022,41(2):633-642.DOI:10.1002/nau.24866.
• [11]Claeys EHI,Mantingh T,Morrens M,et al.Resting-state f MRI in depressive and (hypo)manic mood states in bipolar disorders:a systematic review[J].Prog Neuropsychopharmacol Biol Psychiatry,2022,113:110465.DOI:10.1016/j.pnpbp.2021.110465.
• [12]Zhao C,Huang WJ,Feng F,et al.Abnormal characterization of dynamic functional connectivity in Alzheimer's disease[J].Neural Regen Res,2022,17(9):2014-2021.DOI:10.4103/1673-5374.332161.
• [13]Fan LL,Yu M,Pinkham A,et al.Aberrant large-scale brain modules in deficit and non-deficit schizophrenia[J].Prog Neuropsychopharmacol Biol Psychiatry,2022,113:110461.DOI:10.1016/j.pnpbp.2021.110461.
• [14]Teng CJ,Liu TC,Zhang N,et al.Cognitive behavioral therapy may rehabilitate abnormally functional communication pattern among the triple-network in major depressive disorder:a follow-up study[J].JAffect Disord,2022,304:28-39.DOI:10.1016/j.jad.2022.02.050.
• [15]Zheng XY,Sun JW,Lv YT,et al.Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis:an f MRI Study[J].Sci Rep,2021,11(1):12042.DOI:10.1038/s41598-021-90546-3.
• [16]Zhu W,Che YY,Wang Y,et al.Study on neuropathological mechanisms of primary monosymptomatic nocturnal enuresis in children using cerebral resting-state functional magnetic resonance imaging[J].Sci Rep,2019,9(1):19141.DOI:10.1038/s41598-019-55541-9.
• [17]Jiang KH,Yi Y,Ding L,et al.Degree centrality of key brain regions of attention networks in children with primary nocturnal enuresis:a resting-state functional magnetic resonance imaging study[J].Int J Dev Neurosci,2019,79:32-36.DOI:10.1016/j.ijdevneu.2019.09.007.
• [18]Owens JA,Spirito A,Mc Guinn M.The Children's Sleep Habits Questionnaire (CSHQ):psychometric properties of a survey instrument for school-aged children[J].Sleep,2000,23(8):1043-1051.
• [19]Tomasi D,Volkow ND.Functional connectivity hubs in the human brain[J].Neuro Image,2011,57(3):908-917.DOI:10.1016/j.neuroimage.2011.05.024.
• [20]Chen J,Xu Y,Zhang KR,et al.Comparative study of regional homogeneity in schizophrenia and major depressive disorder[J].Am JMed Genet,2013,162(1):36-43.DOI:10.1002/ajmg.b.32116.
• [21]Jiang KH,Ding L,Li HX,et al.Degree centrality and voxel-mirrored homotopic connectivity in children with nocturnal enuresis:a functional MRI study[J].Neurol India,2018,66(5):1359-1364.DOI:10.4103/0028-3886.241334.
• [22]Uddin LQ,Supekar K,Lynch CJ,et al.Salience network-based classification and prediction of symptom severity in children with autism[J].JAMA Psychiatry,2013,70(8):869-879.DOI:10.1001/jamapsychiatry.2013.104.
• [23]Palaniyappan L,Liddle PF.Does the salience network play a cardinal role in psychosis?An emerging hypothesis of insular dysfunction[J].JPsychiatry Neurosci,2012,37(1):17-27.DOI:10.1503/jpn.100176.
• [24]Tekin S,Cummings JL.Frontal-subcortical neuronal circuits and clinical neuropsychiatry:an update[J].J Psychosom Res,2002,53(2):647-654.DOI:10.1016/S0022-3999(02)00428-2.
• [25]Olejarczyk E,Gotman J,Frauscher B.Region-specific complexity of the intracranial EEG in the sleeping human brain[J].Sci Rep,2022,12(1):451.DOI:10.1038/s41598-021-04213-8.
• [26]Guan QL,Guo J.Research progresses in resting-state functional magnetic resonance in primary insomnia[J].China Med Her,2020,17(1):38-41.关秋莉,郭静.原发性失眠的静息态功能磁共振研究进展[J].中国医药导报,2020,17(1):38-41.
• [27]Wu YY,Zhuang Y,Qi J.Explore structural and functional brain changes in insomnia disorder:a PRISMA-compliant whole brain ALEmeta-analysis for multimodal MRI[J].Medicine,2020,99(14):e19151.DOI:10.1097/MD.0000000000019151.
• [28]Leerssen J,Wassing R,Ramautar JR,et al.Increased hippocampal-prefrontal functional connectivity in insomnia[J].Neurobiol Learn Mem,2019,160:144-150.DOI:10.1016/j.nlm.2018.02.006.
• [29]Wang ZY,Huo JW,Li JQ,et al.Altered brain activity in patients with chronic primary insomnia:a resting-state functional magnetic resonance imaging study[J].Chin J Med Imaging,2020,30(12):2179-2182,2187.王忠艳,霍健伟,李俊秋,等.慢性原发性失眠局部一致性的静息态功能磁共振研究[J].医学影像学杂志,2020,30(12):2179-2182,2187.
• [30]Esposito M,Gallai B,Parisi L,et al.Primary nocturnal enuresis as a risk factor for sleep disorders:an observational questionnaire-based multicenter study[J].Neuropsychiatr Dis Treat,2013,9:437-443.DOI:10.2147/NDT.S43673.