吴开富;何来昌;谭永明;

• 1:南昌大学第一附属医院影像科

摘要(Abstract)：

目的利用扩散张量成像(diffusion tensor imaging,DTI)技术观测脊髓型颈椎病(cervical spondylotic myelopathy,CSM)患者减压术前、术后躯体感觉传导纤维表观弥散系数(apparent diffusion coefficient,ADC)、各向异性分数(anisotropy fraction,FA)及平均扩散系数(diffusion coefficient, MD)变化,探究CSM患者感觉障碍、术后神经功能恢复的结构变化基础。材料与方法 27例CSM术前患者与27名年龄、性别相匹配的健康志愿者接受大脑MRI扫描(DTI数据),27例CSM患者术后6个月再次进行同样扫描,将双侧丘脑皮质束及脊髓丘脑束(丘脑-中脑)作为感兴趣区,对三组ADC、MD及FA值的独立或配对样本t检验,分析各组间传导束FA值、MD值及ADC值的变化,以期揭示慢性颈髓压迫、减压对损伤远端的感觉传导纤维影响。结果与健康对照组相比,CSM术前患者的丘脑皮质束及脊髓丘脑束的FA值均减低(P<0.05),丘脑皮质束及脊髓丘脑束ADC、MD值升高(P<0.05);术后6个月,术后CSM患者丘脑皮质束较术前、对照组FA值均减低(P<0.05),脊髓丘脑束FA值较术前和对照组升高(P<0.05)。结论 DTI数据值可以量化反映继发脊髓损伤远端神经微细损伤,对判断CSM病情及揭示病理生理机制有重要意义;CSM可致脊髓丘脑束及丘脑皮质束发生继发性、逆行性损害,减压术后丘脑皮质神经束康复效能不明显,但是术后脊髓丘脑神经束存在重塑。

关键词(KeyWords)： 脊髓型颈椎病;磁共振成像;丘脑皮质束;脊髓丘脑束

Abstract:

Keywords:

基金项目(Foundation): 国家自然基金项目(编号：81460329);; 江西省自然科学基金(编号：20181BAB205063)~~

作者(Author): 吴开富;何来昌;谭永明;

Email:

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