郭苗;徐国军;余秋蓉;王鹤玮;尹大志;孙莉敏;宁瑞鹏;刘凡;范明霞;

• 1:华东师范大学上海市磁共振重点实验室
• 2:复旦大学附属华山医院
• 3:华东师范大学心理与认知科学学院附属精神卫生中心

摘要(Abstract)：

目的 探究单侧皮质下脑卒中半球间同位脑区经胼胝体结构连接变化与临床运动功能障碍的关系。材料与方法 招募34例单侧皮质下脑卒中患者和43例健康人并采集磁共振弥散张量成像数据。利用高分辨经胼胝体纤维束模板(trancallosal tract template,TCATT)计算并比较卒中组与健康对照组通往半球间同位脑区(包括感觉运动区、前额叶、顶叶、颞叶和枕叶)的32条经胼胝体神经纤维束的各向异性分数(fractional anisotropy,FA)的差异，进一步与皮质脊髓束(corticospinal tract,CST)的FA比率(FA ratio,rFA)和上肢运动功能评分(fugl-meyer assessment of upper extremity,FM-UE)进行相关性分析。结果 与健康对照组相比，卒中组半球间同位脑区的32条经胼胝体神经纤维束在中矢状面区域的FA值均降低，其中差异有统计学意义的有29条(不包括直回、中央旁小叶和内侧眶回的同位脑区经胼胝体纤维束)。这29条经胼胝体神经纤维束在中矢状面区域的FA值与rFA (CST)、FM-UE均存在显著正相关(P<0.05)。卒中组rFA (CST)与FM-UE评分亦呈显著正相关(r=0.596,P=0.0004)。结论 本研究证实皮质下脑卒中的胼胝体微结构受损与病灶同侧CST损伤密切相关。继发性跨半球结构连接损伤对皮质下脑卒中运动功能障碍具有同样重要的影响。

关键词(KeyWords)： 脑卒中;弥散张量成像;经胼胝体神经纤维束;同位脑区;皮质脊髓束;运动功能障碍

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(编号：81974356);国家自然科学基金青年项目(编号：82102665);; 国家重点研发计划(编号：2020YFC2004200)~~

作者(Authors): 郭苗;徐国军;余秋蓉;王鹤玮;尹大志;孙莉敏;宁瑞鹏;刘凡;范明霞;

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