谢宗源;徐香玖;黄刚;周星;马小梅;王治民;铁萍;张庆;

• 1:宁夏医科大学
• 2:甘肃省人民医院放射科
• 3:甘肃中医学院

摘要(Abstract)：

目的探讨直肠癌动态对比增强磁共振成像(DCE-MRI)参数的特点及其与病理分化程度、Dukes分期的关系。材料与方法对56例经病理证实为直肠癌患者的DCE-MRI图像进行回顾性分析,绘制时间-信号强度曲线(TIC)、构建Ktrans、Ve、Kep参数图,并分析TIC、Ktrans、Ve、Kep值的特点及其与肿瘤分化程度、Dukes分期的相关性。结果将直肠癌及肿瘤周围正常直肠壁的TIC分为3种类型,其中Ⅱ型8例,Ⅲ型48例,肿瘤周围正常直肠壁Ⅰ型为41例、Ⅱ型15例。直肠癌的Ktrans值随肿瘤分化程度减低,Dukes分期增加而升高(P值均<0.01);Ve、Kep值差异无统计学意义。结论 DCE-MRI能反映肿瘤内部的血流动力学情况,TIC及Ktrans值与直肠癌的病理分化程度、Dukes分期具有一定相关性,TIC及Ktrans值可能用于评价直肠癌的恶性程度。

关键词(KeyWords)： 直肠癌;磁共振成像;动态增强;时间-信号强度曲线;容量转移常数

Abstract:

Keywords:

基金项目(Foundation): 甘肃省卫生行业科研计划基金项目(编号:GSWST2013-01)

作者(Author): 谢宗源;徐香玖;黄刚;周星;马小梅;王治民;铁萍;张庆;

Email:

参考文献(References)：

• [1]Zhao JL,Guan HT,Li MD,et al.Dynamic contrast-enhanced MR imaging combined with T2*-weighted fi rst-pass perfusion imaging in diagnosis of breast tumor.Chin J Magn Reson Imaging,2014,5(1):54-59.赵金丽,管海涛,李敏达,等.MR动态增强扫描结合T2*WI首过灌注成像诊断乳腺肿瘤的价值.磁共振成像,2014,5(1):5(1):54-59.
• [2]Li M,Jin Z,Li GJ,et al.Correlation between angiogenesis and multiparameters of dynamic contrast enhancement MRI for assessments of benign and malignant breast lesions.Chin J Magn Reson Imaging,2010,1(1):36-42.李敏,金真,李功杰,等.乳腺动态增强MRI参数与肿瘤血管的相关性及其鉴别诊断价值.磁共振成像,2010,1(1):36-42.
• [3]Kim H,Folks KD,Guo L,et al.DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 therapy.Mol Imaging Biol,2011,13(1):94-103.
• [4]Liu L,Wu N,Ouyang H,et al.Diversity and characteristics of prostate cancer in dynamic contrast-enhanced MRI.Chin J Med Imaging Technol,2011,27(12):2506-2509.刘莉,吴宁,欧阳汉,等.前列腺癌动态增强MRI的多样性表现及特点.中国医学影像技术,2011,27(12):2506-2509.
• [5]Franiel T,Hamm B,Hricak H.Dynamic contrast-enhanced magnetic resonance imaging and pharmacokinetic models in prostate cancer.Eur Radiol,2011,21(3):616-626.
• [6]Tofts PS,Brix G,Buckley DL,et al.Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer:Standardized quantities and symbols.J Magn Reson Imaging,1999,10(3):223-232.
• [7]Zhang SJ,Peng WJ,Zhou LP.Basic principles and clinical applications of dynamic contrast-enhanced MRI in prostate cancer.Chin J Med Imaging Technol,2010,26(2):378-380.张盛箭,彭卫军,周良平.动态增强MRI基本原理及其在前列腺癌中的应用.中国医学影像技术,2010,26(2):378-380.
• [8]Wang H,Li J,Chen F,et al.Morphological,functional and metabolic imaging biomarkers:assessment of vascular-disrupting effect on rodent liver tumors.Eur Radiol,2010,20(8):2013-2026.
• [9]Yao WW,Zhang H,Ding B,et al.Rectal cancer:3D dynamic contrast-enhanced MRI;correlation with microvascular density and clinicopathological features.Radiol Med,2011,116(3):366-374.
• [10]Zhou NN,Chen M,Wang WC,et al.Effects of neoadjuvant chemoradiotherapy prior to surgery on rectal cancer assessing by DCEMRI.Chin J Magn Reson Imaging,2010,1(2):103-109.周妮娜,陈敏,王文超,等.动态增强磁共振成像对直肠癌术前新辅助治疗疗效的评价.磁共振成像,2010,1(2):103-109.
• [11]Yankeelov TE,Gore JC.Dynamic contrast enhanced magnetic resonance imaging in oncology:theory,data acquisition,analysis,and examples.Curr Med Iamging Rev,2009,3(2):91-107.
• [12]Kim DJ,Kim JH,Lim JS,et al.Restaging of rectal cancer with MR imaging after concurrent chemotherapy and radiation therapy.Radiographics,2010,30(2):503-516.