磁化传递成像和酰胺质子转移成像联合评价新生儿脑损伤的初步研究Evaluation of brain injury in neonates by magnetization transfer imaging combined amide proton transfer imaging: a preliminary study
郑阳;王晓明;
摘要(Abstract):
目的应用酰胺质子转移成像(amide proton transfer,APT)联合磁化传递(magnetization transfer,MT)成像对新生儿从脑内环境角度评估新生儿脑损伤。材料与方法新生儿共38名,脑损伤13例,为病例组;常规MRI检查脑内无异常25例为对照组。常规MRI检查后补充APT-MT成像扫描。测量所有新生儿双侧额叶深部白质、基底节区、枕叶深部白质的APT值以及磁化传递率(magnetization transfer ratio,MTR)值(以下用APT/MTR表示),以及病例组病灶区及其对侧的APT/MTR值。采用SPSS 19.0软件进行统计分析。结果 (1)对照组中,额叶深部白质、基底节及枕叶深部白质APT/MTR值均有显著性差异(P<0.05)。(2)对照组中,APT/MTR值随孕龄增长而逐渐升高。(3)病例组病灶内APT/MTR值低于对侧(P<0.05)。结论围产期缺氧缺血是全脑代谢变化,APT-MT成像可从内环境及分子水平评估新生儿脑损伤。
关键词(KeyWords): 磁共振成像;新生儿;脑;酰胺质子转移成像;磁化传递成像
基金项目(Foundation): 国家自然科学基金(编号:30570541、30770632、81271631)~~
作者(Author): 郑阳;王晓明;
Email:
DOI:
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