基于22例SAPHO综合征患者全脊柱病变的MRI表现MRI findings of whole spinal in 22 patients with SAPHO syndrome
于梅艳;唐莹;刘军莲;张亚男;黄子玮;霍健伟;李忱;孙渤缘;张文;李俊秋;
摘要(Abstract):
目的评估SAPHO综合征全脊柱病变的MRI表现,探索其影像学规律。材料与方法分析22例SAPHO综合征全脊柱病变MRI图像,对活动性病变和结构性病变及椎旁、椎间隙病变的特征进行评估、统计与分析。结果 SAPHO综合征脊柱受累病变主要在胸段(占脊柱病变的45.4%)(P<0.05),其中活动性病变骨髓水肿(bone marrow edema,BME)和结构性病变脂质沉积最为常见,且均以胸段前侧椎角为主,跳跃分布和对吻分布分别为:BME 53.3%、46.7%,脂质沉积41.3%、58.7%。其他病变包括骨桥(3.9%)、骨质破坏(19.2%)、骨质硬化(3.0%)、椎间隙狭窄(4.3%)、压缩性骨折(3.5%)和椎旁软组织水肿(4.6%)。结论 SAPHO综合征全脊柱病变以胸椎前侧椎角的BME和脂质沉积为主,呈跳跃和对吻分布,具有一定的特征性。
关键词(KeyWords): SAPHO综合征;脊柱;磁共振成像;病例报道
基金项目(Foundation): 中国医学科学院医学与健康科技创新工程项目(编号:2017-I2M-3-001)~~
作者(Author): 于梅艳;唐莹;刘军莲;张亚男;黄子玮;霍健伟;李忱;孙渤缘;张文;李俊秋;
Email:
DOI:
参考文献(References):
- [1]Chamot AM,Benhamou CL,Kahn MF,et al.Acne-pustulosishyperostosisosteitis syndrome.Results of a national survey.85 cases.Rev Rhum Mal Osteoartic,1987,54(3):187-196.
- [2]Earwaker JW,Cotten A.SAPHO:syndrome or concept?Imaging findings.Skeletal Radiol,2003,32(6):311-327.DOI:10.1007/s00256-003-0629-x.
- [3]Li C,Ye Y,Cao Y,et al.Axial skeletal lesions and disease duration in SAPHO syndrome:A retrospective review of computed tomography findings in 81 patients.Int J Rheum Dis,2020 Jun 26.DOI:10.1111/1756-185X.13899.
- [4]Cao Y,Li C,Yang Q,et al.Three patterns of osteoarticular involvement in SAPHO syndrome:a cluster analysis based on whole body bone scintigraphy of 157 patients.Rheumatology (Oxford),2019,58(6):1047-1055.DOI:10.1093/rheumatology/key415.
- [5]Jurik AG,Klicman RF,Simoni P,et al.SAPHO and CRMO:The value of imaging.Semin Musculoskelet Radiol,2018,22(2):207-224.DOI:10.1055/s-0038-1639469.
- [6]Liu S,Tang M,Cao Y,et al.Synovitis,acne,pustulosis,hyperostosis,and osteitis syndrome:review and update.Ther Adv Musculoskelet Dis,2020,12:1759720X20912865.DOI:10.1177/1759720X20912865.
- [7]Carneiro S,Sampaio-Barros PD.SAPHO syndrome.Rheum Dis Clin North Am,2013,39:401-418.DOI:10.1016/j.rdc.2013.02.009.
- [8]Xu WR.Imaging manifestations of spine and sacroiliac joint lesions in patients with SAPHO syndrome and clinical application.Peking Union Medical College,2017:23-24.徐文睿.SAPHO综合征患者脊柱及骶髂关节病变的影像学表现及临床应用.北京协和医学院,2017:23-24.
- [9]Baraliakos X,Coates LC,Braun J.The involvement of the spine in psoriatic arthritis.Clm Exp Rheumatol,2015,33(5Suppl 93):S31-S35.
- [10]Yu M,Cao Y,Li J,et al.Anterior chest wall in SAPHO syndrome:magnetic resonance imaging findings.Arthritis Res Ther,2020,22(1):216.DOI:10.1186/s13075-020-02309-6.
- [11]Cianci F,Zoli A,Gremese E,et al.Clinical heterogeneity of SAPHOsyndrome:challenging diagnose and treatment.Clin Rheumatol,2017,36(9):2151-2158.DOI:10.1007/s10067-017-3751-1.
- [12]Li Y,Huo J,Cao Y,et al.Efficacy of tofacitinib in synovitis,acne,pustulosis,hyperostosis and osteitis syndrome:a pilot study with clinical and MRI evaluation.Ann Rheum Dis,2020,79(9):1255-1257.DOI:10.1136/annrheumdis-2020-217250.
- [13]Himuro H,Kurata S,Nagata S,et al.Imaging features in patients with SAPHO/CRMO:a pictorial review.Jpn J Radiol,2020,38(7):622-629.DOI:10.1007/s11604-020-00953-1.
- [14]Leone A,Victor N,Casale R,et al.The SAPHO syndrome revisited with an emphasis on spinal manifestations.Skeletal Radiol,2015,44(1):9-24.DOI:10.1007/s00256-014-2025-0.
- [15]Gao S,Deng X,Zhang L,et al.The comparison analysis of clinical and radiological features in SAPHO syndrome.Clin Rheumatol,2020,Jun 5.DOI:10.1007/s10067-020-05187-0.
- [16]Takigawa T,Tanaka M,Nakanishi K,et al.SAPHO syndrome associated spondylitis.Eur Spine J,2008,17(10):1391-1397.DOI:10.1007/s00586-008-0722-x.
- [17]Laredo JD,Vuillemin-Bodaghi V,Boutry N,et al.SAPHO syndrome:MR appearance of vertebral involvement.Radiology,2007,242(3):825-831.DOI:10.1148/radiol.2423051222.
- [18]McGauvran AM,Kotsenas AL,Diehn FE,et al.SAPHO syndrome:Imaging findings of vertebral involvement.Am J Neuroradiol,2016,37(8):1567-1572.DOI:10.3174/ajnr.A4736.
- [19]Schaub S,Sirkis HM,Kay J.Imaging for synovitis,acne,pustulosis,hyperostosis,and osteitis (SAPHO) syndrome.Rheum Dis Clin North Am,2016,42(4):695-710.DOI:10.1016/j.rdc.2016.07.011.
- [20]Xie R,Sun D,Morelli JN,et al.Recognition of sacroiliac joint structural lesions:Comparison of volumetric interpolated breath-hold examination (VIBE) sequences with different slice thicknesses to T1-weighted turbo-echo.Eur J Radiol,2020,124:108849.DOI:10.1016/j.ejrad.2020.108849.
- [21]Magrey M,Khan MA.New insights into synovitis,acne,pustulosis,hyperostosis,and osteitis (SAPHO) syndrome.Curr Rheumatol Rep,2009,11(5):329-333.DOI:10.1007/s11926-009-0047-8.
- [22]Depasquale R,Kumar N,Lalam RK,et al.SAPHO:What radiologists should know.Clin Radiol,2012,67(3):195-206.DOI:10.1016/j.crad.2011.08.014.