温馨;陈杰;廖晨希;郑倩华;李瑛;

• 1:成都中医药大学针灸推拿学院
• 2:成都中医药大学研究生院

摘要(Abstract)：

目的 探讨腹泻型肠易激综合征(irritable bowel syndrome with diarrhea,IBS-D)患者静息态下局部脑功能活动的时间变异性。材料与方法 对24例IBS-D患者与20例健康对照者进行静息态功能磁共振成像扫描，采用低频振幅(amplitude of low-frequency fluctuation,ALFF)结合滑动窗法来计算动态低频振幅(dynamic ALFF,dALFF)，并采用Pearson分析IBS-D患者dALFF值的变化与肠易激综合征(irritable bowel syndrome,IBS)症状严重程度得分、IBS生活质量得分、IBS患者腹痛程度等临床指标的相关性。结果 dALFF比较结果显示，IBS-D患者左侧小脑(t=3.95)及右脑壳核(t=3.13) dALFF变异性升高(Alphasim校正，P<0.01)。相关性分析显示，右侧壳核dALFF变异性异常与IBS-D患者的腹痛程度呈正相关(r=0.398,P=0.054)。结论 IBS-D患者的左侧小脑和右侧壳核表现出自发神经活动的时间变异性的异常。此外，右侧壳核可能是IBS-D患者腹痛症状发生、发展的相关脑区。

关键词(KeyWords)： 肠易激综合征;静息态功能磁共振成像;低频振幅;动态变化;壳核

Abstract:

Keywords:

基金项目(Foundation): 国家重大研发计划(编号：2019YFC1712103);; 国家自然科学基金委员会青年基金项目(编号：81804207)~~

作者(Authors): 温馨;陈杰;廖晨希;郑倩华;李瑛;

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