牛俊霞;冉云彩;张勇;王潇;白洁;张焱;

• 1:郑州大学第一附属医院磁共振科

摘要(Abstract)：

目的 探讨颅内非典型性畸胎样/横纹肌样肿瘤(atypical teratoid/rhabdoid tumor,AT/RT)的MRI表现特征及其与Ki-67标记指数的相关性。材料与方法 回顾性分析本院2013年11月至2021年5月经手术病理证实的11例颅内AT/RT病例的MRI表现，并进一步研究MRI表现与Ki-67标记指数的相关性。结果 11例颅内AT/RT中9例发生于后颅窝；肿瘤最大径为(37.08±2.57) mm;8例病灶出现囊变；6例病灶出现出血；3例病灶周围有轻度水肿；扩散加权成像(diffusion weighted imaging,DWI)(b=1000 s/mm2)示7例扩散受限高信号，4例轻度扩散受限稍高信号。1例患者未行MR增强扫描，其余7例呈明显不均匀强化，3例呈轻度不均匀强化。Ki-67标记指数范围为30%～80%，高表达组(Ki-67>40%) 6例，低表达组(Ki-67≤40%) 5例，两组在肿瘤位置、肿瘤最大径、瘤内出血、瘤内囊变、瘤周水肿、增强程度方面差异无统计学意义，但两组表观扩散系数(apparent diffusion coefficient,ADC)值差异有统计学意义(P<0.05)。Spearman秩相关分析显示ADC值与Ki-67标记指数呈负相关(r=-0.866,P<0.01)。结论 颅内AT/RT常有囊变、出血，MRI信号多不均匀，增强扫描多呈不均匀明显强化；ADC值与Ki-67标记指数呈负相关。

关键词(KeyWords)： 非典型性畸胎样/横纹肌样肿瘤;胚胎性肿瘤;磁共振成像;Ki-67标记指数;表观扩散系数

Abstract:

Keywords:

基金项目(Foundation): 河南省医学科技攻关计划(编号：2018010007)~~

作者(Authors): 牛俊霞;冉云彩;张勇;王潇;白洁;张焱;

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